TheAgingGapBetweenSpecies

The Aging Gap Between Species [電子書籍版]
Anca Ioviţă

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商品基本情報

  • 著者:   Anca Ioviţă
  • 発売日:  2015年09月29日
  • 出版社:  Anca Ioviţă
  • 商品番号:  1230000692687
  • 言語:  English

商品説明

Aging is a puzzle to solve. This process is traditionally studied in a couple of biological models like fruit flies, worms and mice. What all these species have in common is their fast aging. This is excellent for lab budgets. It is a great short-term strategy. Who has time to study species that live for decades? But lifespan differences among species are magnitudes of order larger than any lifespan variation achieved in the lab. This is the reason for which I studied countless information resources in an attempt to gather highly specialized research into one easy-to-follow book. I wanted to see the forest among the trees. I wanted to expose the aging gap between species in an easy-to-follow and logical sequence. This book is my attempt at doing just that. What are the mechanisms underlying the aging gap between species? I intentionally chose to write the answer to this question in plain English. Aging research is too important to hide it behind the closed doors of formal scientific jargon. This book could not have existed if green tea, libraries and the Internet were not invented. The amount of data I had to browse in order to keep the essential patterns is huge. Yet this book is not exhaustive. This is not a dry academic textbook. I tried to instill life in a topic that is hugely important for the extension of human lifespan. Only you can decide if I achieved this.


Contents


 


Finding the Forest Among the Trees


Being Reliable Counts


The Mathematics of Aging


The Speed of Senescence


Case Study: Aging in Fish


How to Estimate Chronological Age


Taking Life Slowly


On Temperature and Aging


Dormancy


The Housekeeping Problem


Case Study: Aging in Turtles


Intracellular Junk


Case Study: Aging in Crustaceans


Extracellular Junk


Case Study: Protein Quality Control


The Sweet Poison


Are Cell Membranes the Pacemakers of Metabolism?


Could Reproduction Set up the Pacemaker of Senescence?


The Segregation of Somatic and Germ Cells


Clonal Senescence Versus Mechanical Senescence


Same Species, Different Lifespans


Case Study: Eusocial Species


Case Study: Parasite/Free-Living Populations


Case Study: Island Versus Inland Populations


Hormones as Pacemakers of Senescence


Case Study: Low Hormone Levels in Long-lived Rodents


Is Aging a Form of Dehydration?


The Immune Pacemaker of Senescence


Innate Versus Adaptive Immunity


Senescent Cells


Case Study: Thymic Involution in Negligible Senescence Species


Reverse Engineering the Body


Case Study: Why Are Sponges Potentially Immortal?


Modular Growth and Aging


Case Study: Youth Is Forever Gone. Unless You Are a Hydra. Or an Immortal Jellyfish


Down The Neoteny Lane


Case Study: Neoteny in Amphibians


Case Study: Neoteny in Mammals


It's All About Neoteny


Does Aging Start When Growth Stops?


Case Study: Indeterminate Growth in Crustaceans


The Rate of Growth


Case Study: Aging in Bivalves


Is Telomerase The New Fountain of Youth?


Case Study: Same Species, Different Telomerase Expression


Telomerase Gene Therapy


Case Study: Sea Urchins


Perennial Plants and Their Regenerating Roots


Case Study: The Bristlecone Pine


Unitary Versus Colonial Organisms


Cancer


The Paradox of Peto


Case Study: Cancer in Long-Lived Species


The End


Acknowledgments


Bibliography

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