Pentamycin-anewoptionforthetreatmentofinfectionswithTrichomonasvaginalis?

Pentamycin - a new option for the treatment of infections with Trichomonas vaginalis? (GRIN Verlag) [電子書籍版]
Markus Kranzler

4,050円(税込)

獲得ポイント:


初めての方限定!1冊無料クーポンプレゼント!
初めての方限定!1冊無料クーポンプレゼント!

商品基本情報

商品説明

Diplomarbeit aus dem Jahr 2011 im Fachbereich Biologie - Mikrobiologie, Molekularbiologie, Note: 1, Universität Wien, Sprache: Deutsch, Abstract: The protozoan parasite Trichomonas vaginalis is the causative agent of trichomonosis which is - with more than 170 million new cases each year - the most prevalent non-viral sexually transmitted disease (STD) worldwide. Although trichomonosis is not a primarily lethal disease, the clinical picture can include severe urogenital inflammations. Chronic infections have been associated with cervical/prostate cancer and a predisposition of HIV infections. In case of pregnancy, chronic infections can also lead to preterm delivery and low birth weight. For more than 50 years, metronidazole, a nitroimidazole antibiotic, has been in use for the treatment of trichomonosis. It is applied orally and although it is mostly compliant, it can have serious side effects. It is also not applicable for pregnant women due to its ability to pass the placenta. Furthermore, an increasing number of emerging metronidazoleresistant T. vaginalis strains has lead to more treatment failures in the last few years. To this day, however, there is no effective alternative drug against trichomonosis available. Pentamycin is a polyene antimycotic and has been in use in the treatment of candidiasis, in preliminary studies it also turned out to be effective against trichomonads. The aim of this study was to evaluate the efficacy of pentamycin against T. vaginalis and the ability to develop resistances in vitro. For these purposes, the dose-effect relationship between pentamycin and four differently metronidazole-sensitive T. vaginalis strains was investigated. Moreover, the protein composition before and after the treatment was compared. To induce resistance, strains were treated with sublethal concentrations of pentamycin within a time of six months. It could be shown that pentamycin is highly effective against T. vaginalis. A 100% eradication of trichomonads was reached with a concentration of 15 ;g/ml and an incubation time of 1h. All four differently metronidazole-sensitive strains showed almost the same sensitivity to pentamycin. The comparison of the protein profiles of untreated and treated cells analysed by SDS-PAGE showed that the mode of action of pentamycin is based on an interaction and subsequent damage of the cell membrane which consequently leads to total lysis and death of the cell. [...]

みんなのレビュー

この商品にはまだレビューがありません レビューを書く

楽天ブックスランキング情報

  • 週間ランキング

    ランキング情報がありません。

  • 日別ランキング

    ランキング情報がありません。

ご購入はこちらから

楽天Kobo電子書籍版

4,050円(税込)

お気に入りに追加
  • 電子書籍のお得なクーポン・キャンペーン

  • 人気コミックや最新の雑誌など!今すぐ読める無料作品をご紹介♪人気コミックや最新の雑誌など!今すぐ読める無料作品をご紹介♪
  • もっと見る
全品対象!
2017/8/10(木) 23:59まで
祝勝利!楽天イーグルス
エントリーで
ポイント2倍
全品対象!
2017/8/10(木) 23:59まで
男性の方限定!
10%OFF
クーポン

最近チェックした商品

    ※表示を削除したい場合は閲覧履歴のページから削除お願いいたします

    ランキング:電子書籍

    ※1時間ごとに更新

    1. 1
      進撃の巨人 attack on titan
      電子書籍進撃の巨人 attack on titan

      諫山創

      432円(税込)

    2. 2
      ダンジョン飯 5巻
      電子書籍ダンジョン飯 5巻

      九井 諒子

      670円(税込)

    3. 3
      七つの大罪
      電子書籍七つの大罪

      鈴木央

      432円(税込)

    4. 4
      DAYS
      電子書籍DAYS

      安田剛士

      432円(税込)

    5. 5
      ちはやふる
      電子書籍ちはやふる

      末次由紀

      432円(税込)

    購入データ自動連携!楽天ブックス公式 無料 読書管理パプリ Readee

    このページの先頭へ